Evexias Hormone Therapy

Rediscover your vibrant self with bioidentical hormones

As we age, our bodies undergo a decline in hormone production that can dramatically affect our quality of life. Those changes you’ve noticed — persistent fatigue, inexplicable weight gain, diminishing sexual desire, mood fluctuations, insomnia — might not just be part of “getting older”. Instead, they may be signs of a hormone imbalance.

While hormonal issues are often addressed with therapies like pills, patches and creams, these methods can be inconsistent and inconvenient. They require daily upkeep and deliver unpredictable results. EvexiPEL changes all that by offering bioidentical hormone replacement therapy in a user-friendly pellet form.

Administration

Pellet

Initial Results

1 week

Full Results

3 months

Frequency (Women)

Every 3-4 months

Frequency (Men)

Every 4-6 months

What Is EvexiPEL® Hormone Replacement Therapy?

Hormone replacement therapy (HRT) addresses the natural decline in hormone production that occurs with aging. As we enter our 40s and beyond, both men and women experience hormonal shifts that can trigger unwelcome symptoms.

Men face andropause, or “male menopause,” characterized by gradually decreasing testosterone. For women, perimenopause and menopause come with sinking estrogen and progesterone levels. These hormonal deficiencies can manifest as fatigue, weight gain, brain fog, mood disturbances and diminished sexual function.

Traditional hormone replacement therapies attempt to restore hormonal balance by delivering synthetic hormones into the body via pills, patches, creams or injections. These methods can provide relief, but they often require daily administration and produce inconsistent hormone levels that mimic the very imbalance they aim to correct.

EvexiPEL uses tiny, custom-compounded pellets — about the size of a grain of rice — inserted just beneath the skin in a simple in-office procedure. These pellets are crafted from bioidentical hormones, which means they’re structurally identical to the hormones your body naturally produces. Once placed, the pellets release a steady stream of hormones, providing consistent levels for three to six months depending on your individual needs.

Why Is EvexiPEL® the Preferred Hormone Treatment at RSMD?

Dr. Burns selected EvexiPEL as RSMD’s hormone therapy of choice after extensive research and evaluation. As with all treatments offered at our practice, this decision was based on science, not marketing hype or passing trends.

Quality

EvexiPEL’s patented pellet formulation is developed in an FDA-registered 503B outsourcing facility under stringent quality controls.

Comfort

EvexiPEL’s pellets contain an anti-inflammatory ingredient that enhances patient comfort and reduces complications.

Safety

Clinical studies show that patients receiving EvexiPEL experience significantly fewer pellet extrusions compared to those treated with alternative methods.

Consistency

EvexiPEL pellets mimic your body’s innate hormone regulation patterns more closely than other delivery methods, increasing and decreasing as needed.

Convenience

Pellets do not require the hassles of daily application or the mess of topical products.

Natural Ingredients

EvexiPEL hormones are sourced from natural products like yams and soy. The ingredients in the pellets are FDA approved.

What Are the Benefits of EvexiPEL®?

EvexiPEL’s unique delivery system and bioidentical formulation create an experience that patients find remarkably different from other hormone therapies they may have tried in the past. Benefits include:

Bioidentical hormones that match the molecular structure of those naturally produced by your body
Enhanced bioavailability and reduced side effects due to the hormones’ natural composition
Long-lasting results from each treatment, typically 3-6 months depending on individual factors
Customized dosing based on your specific lab values, symptoms and health goals
Minimal risk of hormonal transfer to family members (unlike with creams and gels)

"The steady hormone delivery that EvexiPEL provides is a game-changer. The pellets work around the clock, releasing hormones in response to your body's demands. This creates a more natural hormonal rhythm that many patients describe as feeling 'normal again' rather than experiencing the artificial highs and lows associated with other HRT methods. I've seen remarkable transformations in patients who previously felt like they had tried everything without success." --- Dr. Burns

What Concerns Can HRT Target?

The hormonal systems of your body influence virtually every cellular function, which explains the wide variety of symptoms that can occur when hormone levels change.

For women, estrogen and progesterone fluctuations can lead to:

Hot flashes
Night sweats
Fatigue
Mood swings
Difficulty concentrating
Vaginal dryness
Decreased libido
Painful intercourse
Anxiety
Depression
Accelerated skin aging
Unexplained weight gain

For men, low testosterone (low-T) may create its own set of challenges:

Reduced muscle mass
Increased body fat
Decreased strength and endurance
Reduced libido
Difficulty achieving or maintaining erections
Diminished sexual satisfaction
Brain fog
Poor concentration
Irritability
Depression
Anxiety
Disrupted sleep patterns and fatigue

Hormone deficiencies may also have long-term consequences, including increasing risk of osteoporosis and cardiovascular issues.

Am I a Good Candidate for EvexiPEL®?

The ideal candidates for EvexiPEL hormone therapy are men and women experiencing symptoms of hormone deficiency who desire a convenient long-term solution.

Patients typically begin to notice signs of hormonal imbalance in their 40s or 50s, though some may develop symptoms earlier due to stress, medical conditions or genetic factors. If you’ve noticed that your body doesn’t respond to diet and exercise the way it once did, or if you feel like you’ve “lost your edge” mentally or physically, hormone optimization could be the missing piece in your health puzzle.

Before recommending EvexiPEL, your RSMD provider will conduct a comprehensive consultation and hormone testing to determine whether EvexiPEL pellets are an appropriate treatment for you.

Just 4 Simple Steps to Bring Your Skin to Life™

Book your HRT consultation at Resurrect Skin MD
Undergo an evaluation with our physician extender and wellness RN
Receive your personalized treatment plan and lifestyle guidance
Experience relief from your symptoms and rediscover your vitality!

What Should I Expect During My EvexiPEL® Treatment?

Our comprehensive approach ensures you receive personalized care from initial consultation through ongoing treatment. Your HRT treatment will include the following:

Consultation

Your EvexiPEL experience begins with a thorough consultation. During this visit, we’ll discuss your symptoms, health concerns and goals for hormone therapy, as well as your medical history, current medications and lifestyle factors that may influence your hormonal health.

Based on this information and your lab results, we’ll develop a customized treatment plan tailored to your specific needs and explain exactly how EvexiPEL therapy can help restore your hormonal balance.

Hormone Testing

Your consultation includes comprehensive hormone testing to confirm that your symptoms are indeed hormone-related and to establish your baseline levels. Our testing goes beyond the standard panels offered by many practitioners, examining not just total hormone levels but also free hormones, metabolites and related markers that influence hormonal function.

This thorough approach ensures that your treatment plan is personalized and addresses the root causes of your symptoms rather than simply masking them.

Pellet Insertion

EvexiPEL pellet insertion is a simple procedure performed in our office that typically takes less than 15 minutes. Before beginning, we thoroughly cleanse the insertion area (usually the upper buttock or hip area) and administer a local anesthetic.

Once the area is numb, your provider will make a small incision and insert the pellet just beneath the skin. The small incision is closed with surgical glue or a sterile adhesive strip—no sutures are required.

Follow Up

We typically schedule a follow-up appointment four to six weeks after pellet insertion to assess your response to treatment. At this visit, we’ll conduct follow-up laboratory testing to assess your hormone levels and discuss any changes you’ve noticed in your symptoms.

Based on your results and feedback, we may adjust your treatment plan for future pellet insertions. We continually refine your EvexiPEL treatment plan based on your clinical response, laboratory values and personal feedback so you receive the maximum benefit from your therapy.

Are There Side Effects From HRT?

Hormone replacement therapy can produce side effects, though most patients experience minimal or no adverse reactions with EvexiPEL. The incidence of side effects is significantly lower with bioidentical hormones than with synthetic hormone therapies, and the pellet delivery method helps prevent many of the issues associated with other forms of hormone replacement.

HRT must be properly administered and monitored by trained professionals. At Resurrect Skin MD, we minimize potential complications through precise dosing, careful insertion technique and regular follow-ups to ensure your hormone levels remain within the optimal range.

"Most patients initially seek hormone therapy for relief from immediate symptoms like fatigue or hot flashes, but the long-term benefits are even more significant. Proper hormone balance supports cardiovascular health, maintains bone density, preserves cognitive function and protects muscle mass—all critical factors in how well we age. I tell my patients that hormone optimization isn't just about feeling better today; it's an investment in healthier aging for decades to come." --- Dr. Burns

What Results Are Expected With EvexiPEL®?

Many patients report feeling an initial surge of energy and mental clarity within the first week after pellet insertion. This early response is often followed by improvements in sleep quality and mood stabilization as your body begins to adapt to restored hormone levels. Sexual function typically improves within the first month, with enhanced libido and performance for men and increased desire and comfort for women.

By weeks four to six, most patients experience relief from the majority of their hormone-related symptoms. Physical changes become more noticeable during this period, with many patients reporting improved muscle tone, decreased body fat and enhanced skin quality. Mental and emotional benefits often include sharper cognition, better memory and greater emotional resilience.

The full benefits of EvexiPEL therapy generally manifest by the three-month mark, when hormone levels have fully stabilized and your body has had time to respond to the hormonal optimization. At this point, most patients report feeling like “themselves again” or even better than they have in years. These benefits continue throughout the duration of each pellet cycle.

Most patients require pellet replacement every three to six months, with women typically needing more frequent insertions than men due to differences in metabolism and hormone requirements.

How Long Will I Continue HRT?

Hormone replacement therapy with EvexiPEL is typically approached as a long-term strategy rather than a short-term fix. The natural decline in hormone production is not a temporary condition but a permanent physiological change that continues throughout the aging process. Consequently, the benefits of HRT generally last only as long as treatment continues.

Most patients who see benefit from the treatment choose to continue it indefinitely. As your body changes over time, your hormone requirements may shift, and we may adjust your pellet dosing or complementary treatments in response.

What Complimenting Services Are Available at RSMD?

At Resurrect Skin MD, we view hormone optimization as part of a comprehensive approach to health and aging. We offer many complimenting services that can enhance your results and target specific concerns, such as:

Fat Reduction

CoolSculpting Elite can help with stubborn fat deposits that persist despite hormone balance and healthy habits. This advanced fat-reduction technology uses controlled cooling to eliminate resistant fat cells permanently without surgery.

Muscle Toning

Accufit is an innovative muscle-building technology that strengthens and tones muscle tissue beyond what’s possible with exercise alone. This treatment is particularly valuable for counteracting the muscle loss that often accompanies hormone decline.

Skin Rejuvenation

From advanced laser treatments like HALO and Moxi to cutting-edge technologies like BBL HERO, Genius RF microneedling, INDIBA and Sofwave, we offer solutions for regenerating collagen and treating virtually every skin concern.

Skincare Products

For optimal results, many patients incorporate a skincare routine into their treatment plan. Our skincare experts can recommend products from our favorite medical-grade skincare lines that target the specific benefits you’d like to see in your skin.

Dr. Burns and our team will partner with you to develop an individualized long-term strategy that addresses all of your cosmetic and wellness goals.

Restore Your Vitality With EvexiPEL® at Resurrect Skin MD

Proper hormone balance is essential for looking and feeling your best. Our team has helped countless patients transform their lives through optimized hormone levels, and we’re ready to do the same for you.

With EvexiPEL, you can reclaim the energy, mental clarity and zest for life that hormone imbalance has diminished. Contact us today at 219-754-6865 or through our convenient online contact form to begin your journey to hormone harmony.

Your future self will thank you for taking this important step toward better health and well-being.

FAQs

You have questions? We have answers.

What is EvexiPEL?

EvexiPEL is the flagship therapy of EVEXIAS Health Solutions. This method delivers life-changing bioidentical hormone therapy. EVEXIAS achieves this exclusively through strategic partnership with a leading compounding pharmacy and FDA-registered 503B outsourcing facility. This comprehensive approach combines physiological principles with innovative techniques to optimize hormone levels in both women and men.

How do I know if I’m a candidate for pellets?

If you experience a combination of fatigue, depressed mood, and lower/absent libido, you may have Androgen Insufficiency Syndrome (AIS). Hormone Replacement Therapy (HRT) is a highly effective treatment for AIS. Additionally, if you prefer a minimally invasive procedure every 3-4 months (4-6 months for men), you are an ideal candidate. Other symptoms that often improve with bio-identical hormone optimization include insomnia, early waking, anxiety, lack of energy/drive, lethargy, joint pain, and daytime sleepiness. To confirm a suspected diagnosis of AIS and begin your evaluation, your physician will order lab work to assess your hormone levels. These results will be discussed during your initial consultation

Do I have blood work done before each treatment?

Initial bloodwork is performed to establish baseline hormone levels, aid in diagnosing AIS, and assess any imbalances in other major hormone systems (e.g., adrenal, thyroid). These values will help determine your initial dosage. Four weeks after your first pellet insertion, you will have repeat labs (a smaller panel). These results will be reviewed at your six-week follow-up visit. Thereafter, a full panel of labs is drawn annually. If you experience any significant changes in symptoms related to hormone therapy, your nurse practitioner will recommend reassessment at that time

What are the pellets made from?

The EvexiPEL method features the patented – pellet that is plant based and derived from yams and designed to be an exact replication of what the body produces in contrast to synthetic hormones. This pellet is specifically designed to improve patient comfort and deliver sustained, steady dosing throughout the treatment cycle.

How long will the treatment last?

For women, the effects typically last an average of 3-4 months. Very active individuals may require therapy every 3 months or sooner, while less active or elderly individuals may experience benefits for longer than 4 months. In men, the typical cycle ranges from 4-6 months. The return of early symptoms of hormone insufficiency, such as fatigue, joint pain, or decreased libido, can indicate the need for your next insertion.

Is the therapy FDA approved?

The individual ingredients within the pellets are FDA-approved, and the distribution of these pellets is regulated by the FDA. However, the pellet insertion procedure itself is not FDAapproved. It’s common for physicians to prescribe medications or therapies for uses not explicitly approved by the FDA (off-label) if they believe them to be safe and effective for their patients. The reason bio-identical hormones (compounded drugs) are not FDA-approved is due to their individualized dosing nature.

How are they administered?

Pellets are inserted using a very minor surgical procedure, performed in the office setting and requiring only local anesthesia. Using a very small incision (~ 1-2 cm in women, ~ 3-4 cm in men), they are inserted subcutaneously below the belt and above the buttock in women, and in the posterior flank in men. Recovery is very quick and uncomplicated; exercise restrictions for 3 days in women and 5 days in men are simply to avoid complications.

Does it matter if I’m on birth control?

Not at all. Certain types may have an influence on therapy, which your physician/provider will review with you.

Are there any side effects?

There are no serious or permanent side effects. In some cases, nuisance side effects can occur, such as hair growth or acne, both of which are very treatable.

What if I’m already on some form of HRT, like creams, patches, or pills?

Transitioning to pellet therapy from other forms of HRT is common. Your physician can assess your needs even if you’re currently using another type of hormone replacement therapy. If you prefer to continue with your current HRT but are not ready for pellets, we can offer alternative formulations.

What if I’ve had breast cancer?

There is no direct causative link between bio-identical estrogen, progesterone, and breast cancer. The Women’s Health Initiative (WHI) study in 2003 raised concerns about “hormones and breast cancer,” but a long-term follow-up study published in JAMA in 2017 by one of the original WHI authors found no increased mortality from breast cancer in the subjects over an 18- year period. The number of patients receiving HRT 5 to 10 years after breast cancer treatment and remission is increasing. However, hormone use in patients with a history of hormone-receptor-positive tumors is not yet considered standard care. The decision to use hormones in this situation is an informed one that the patient must make for herself. Finally, patients with or recently recovered from breast cancer can receive testosterone alone to help manage both AIS and menopausal symptoms.

Evexias Hormone Therapy